产品名称:重组人胰岛素样生长因子1(IGFI)

产品英文名称:Human IGF1 Protein

货号:PRP1955

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<1.0 EU。

重组人胰岛素样生长因子1(IGFI)产品背景:
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

序列:
氨基酸序列来源于:重组人胰岛素样生长因子1(IGFI) (P05019-1) (Gly49-Ala118) 表达的蛋白片段。

标签:无标签

活性:
通过其诱导MCF-7细胞增殖的能力来测定。该效应的ED50为76.41 ng/mL。

蛋白长度:
重组人胰岛素样生长因子1(IGFI) 由71个氨基酸组成,预测分子量为7.8 KD。

分子:
Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

检测指标:
Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,150 mM NaCl,pH 7.4。

重组人胰岛素样生长因子1(IGFI)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。