产品名称:重组人神经调节蛋白1-β1(NRG1-β1)

产品英文名称:Human NRG1 Beta1 Protein

货号:PRP1954

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<1.0 EU。

重组人神经调节蛋白1-β1(NRG1-β1)产品背景:
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44 kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

序列:
氨基酸序列来源于:重组人调蛋白-1 β1 Q02297 (S20-K241) 表达的蛋白片段。

标签:无标签

活性:
通过其诱导MCF-7细胞增殖的能力来测定。该效应的ED50为0.6730 ng/mL。

蛋白长度:
重组人调蛋白-1 β1由220个氨基酸组成,预测分子量为24.04 KD。

分子:
ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

检测指标:
ARIA; NRG1; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,150 mM NaCl,pH 7.4。

重组人神经调节蛋白1-β1(NRG1-β1)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。