产品名称:重组小鼠RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1)

产品英文名称:Mouse RSPO1/R-spondin-1 Protein

货号:PRP1303

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。

重组小鼠RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1)产品背景:
RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.

序列:
氨基酸序列来源于:小鼠源RSPO1 (Q9Z132) (Ser21-Gln265) 表达的蛋白片段。

标签:无标签

活性:
Testing in Progress

蛋白长度:
重组小鼠RSPO1由245个氨基酸组成,预测分子量为27.2KD。

分子:
RSPO1

检测指标:
RSPO1

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,50 mM NaCl,pH 8.0。

重组小鼠RSPO1/R-spondin-1 蛋白(RSPO1/R-spondin-1)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于109 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。