产品名称:重组小鼠骨形态发生蛋白4,His-标签(BMP-4)

产品英文名称:Mouse BMP-4 Protein, His tag

货号:PRP1227

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。

重组小鼠骨形态发生蛋白4,His-标签(BMP-4)产品背景:
Bone morphogenetic protein 4 (BMP4) is a multifunctional ligand protein belonging to TGF β Family. BMP4 is expressed by endothelial cells (EC) in response to hypoxia and promotes proliferation of vascular smooth muscle cells (SMC). For example, it inhibits the proliferation of SMCs isolated from the proximal pulmonary artery while inducing the proliferation of SMCs isolated from the distal pulmonary artery. BMP4 seems to be a marker and driver of vascular calcification, especially in atherosclerosis. BMP4 induces angiogenesis, endothelial cell (EC) proliferation, and migration. BMP4 is differentially expressed in calcified atherosclerotic plaque, which is the junction between atherosclerotic vascular calcification and normal bone formation mechanism. BMP4 increases plaque formation, promotes oxidative stress, endothelial dysfunction and osteogenic differentiation through its proinflammatory and atherogenic effects.

序列:
氨基酸序列来源于:小鼠BMP-4? (P21275) (Lys303-Arg408)表达的蛋白片段。

标签:His-标签

活性:
Testing in progress.

蛋白长度:
重组小鼠BMP-4由106个氨基酸组成,预测分子量为12.1KD。

分子:
BMP-4

检测指标:
BMP-4

产品形式:冻干粉,冻干缓冲液为无菌的PBS,pH 4.0。

重组小鼠骨形态发生蛋白4,His-标签(BMP-4)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。