产品名称:重组人白介素17A(IL-17A)

产品英文名称:Human IL-17A Protein

货号:PRP1226

产品特点&优势:
通过LAL法测定,每微克蛋白里内毒素含量<0.1 EU。

重组人白介素17A(IL-17A)产品背景:
Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6.

序列:
氨基酸序列来源于:人IL-17A (Ile20-Ala155) (Q16552) 表达的蛋白片段。

标签:Null

活性:
Testing in progress.

蛋白长度:
重组人IL-17A由136个氨基酸组成,预测分子量为15.7 KD。

分子:
IL-17A

检测指标:
IL-17A

产品形式:冻干粉,冻干缓冲液为无菌的20 mM Tris,50 mM NaCl,pH 8.0。

重组人白介素17A(IL-17A)产品注意事项:
开盖使用前,请先离心。本产品为冻干粉,推荐用该产品配套的Reconstitution Buffer进行复溶,且浓度不低于100 μg/mL。客户可根据后续的实验需求,进行进一步的稀释。

警告:
本文列出的产品仅供研究使用,不适用于人类或临床诊断。我们产品所推荐应用,不是建议使用我们的产品去违反任何专利或许可证。对于使用本产品可能发生的专利侵权或其他违规行为,我们不承担任何责任。